Stem Cell Therapy: A Comprehensive Literature Review of Applications, Properties, and Medical Potential
Overview
This paper presents a systematic literature review of stem cell therapy, examining the biological properties of stem cells including self-renewability and plasticity, and their applications in treating various diseases such as cancer, heart disease, and spinal cord injuries. The study synthesizes current research on stem cell sources, mechanisms of differentiation, and the therapeutic potential of stem cell-based regenerative medicine.
What this literature review covers
- Introduction covering stemness properties, self-renewability, and biological mechanisms of stem cell division
- Literature review synthesizing existing research on stem cell characteristics and applications
- Research methodology including systematic search strategy and data collation procedures
- Results presented through PRISMA flow diagram analysis
- Discussion of findings and clinical implications
- Conclusion with study limitations and recommendations for future research
Preview
Stem Cell Therapy
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Table of Contents
Title Page.1
Table of Contents2
Chapter 1: Introduction3
1.1 Justification5
1.2 Problem Statement6
1.3 Aim of the Research Study6
1.4 Objectives of the Research Study7
Chapter 2: Review of the Literature7
Chapter 3: Research Methodology11
3.1 Identifying the Research Question13
3.2 Identifying the Relevant Studies13
3.3 The Search Strategy13
3.4 Collating the Data14
Chapter 4: Results20
4.1 Block Diagram: Prisma Flow Diagram20
Chapter 5: Discussion25
Chapter 6: Conclusion, Limitations, and Recommendation35
6.1 Conclusion35
6.2 Limitations35
6.3 Recommendations35
References37
- Chapter One: Introduction
The word “stemness” denotes properties that differentiate a heterogeneous cell population variety. In biology stem cells, abbreviated as (SCs) are classified by their self-renewability (O’Brien & Barry, 2009). That is, they have the ability to divide themselves continuously. Also, they can create new progenitors and SCs that are more distinguished than the mother cells. Asymmetric mitosis enhances the creation of intrinsic daughter cells. During the process, a mother cell polarizes causing the localization of the cell-fate factor molecules on one side. The mitotic spindle thereafter aligns itself to the polarity of the cell axis perpendicularly. The process ends with the creation of two different cells.
Lodi et al. (2011) explain that stem cells portray increased level of plasticity such as adopting the cells functional phenotypes, expression profile and crossing the lineage barriers. The plasticity is explained by fusion, and the cells indirect/direct trans-differentiation. Besides, fusion enables the cell to acquire a parenchyma phenotypic element and to express its gene.
Frati et al.