Cell Membrane-Coated Nanotherapeutics: Biomimetic Design for Advanced Cancer Treatment and Disease Management
Overview
This paper provides a comprehensive overview of cell membrane-coated nanotechnology and its applications in nanomedicine, particularly for cancer therapy. It examines how researchers are leveraging natural cell membranes as biomimetic coatings for nanoparticles to improve bio-interfacing capabilities and therapeutic efficacy compared to synthetic approaches. The review explores the technology's potential in clinical translation while discussing emerging applications beyond cancer treatment.
What this literature review covers
- Introduction to Cell Membrane-coated Nanotechnology & Cancer Therapy: Overview of nanoparticle-based therapeutics and the shift toward biomimetic design strategies
- Biomimetic Design and Synthetic Functionalization: Comparison of bottom-up fabrication techniques and the advantages of natural cell membrane approaches
- Applications and Clinical Potential: Discussion of current and emerging applications including cancer treatment, immunological tolerance, and bacterial resistance
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Cell membrane-coated nanotherapeutics
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Abstract
The continued advancements in biomedical nanomedicine has provided better opportunities for clinicians to detect, treat, manage, and prevent human diseases. To push the limits of nanoparticle functionality and performance, experts have adopted a paradigm shift towards biomimetic design techniques. Inspired by nature, these strategies are aimed at creating next-generation nanoparticle platforms that can navigate and interact with the complex biological systems in the body in a more effective way. This paper provides a comprehensive overview of the cell membrane coated nanotechnology. Data is obtained from analyzing previous works of different researchers who have directly leveraged biomaterials obtained from the cell membrane to design novel nanodiagnostics and nanotherapeutics. This technology presents innumerable benefits that make it capable of covering various approaches in medicine. Although it has not been fully translated to the clinic, researchers believe that nanocarriers with benefits in human health will be designed in the future.
Keywords: nanotechnology, biointerfacing, cell membrane, cancer treatment, macrophage
Part 1
Introduction to Cell Membrane-coated Nanotechnology & Cancer Therapy
Nanoparticle‐based therapeutic, detection, and prevention modalities have a great potential of impacting the diagnosis and management of diseases. The availability of several nano-materials has resulted in the increased popularity of rational design nanocarriers based on specific applications. Cell‐membrane‐coating nanotechnology is one of the popular emerging techniques. These upcoming technologies have the potential of advancing nanomedicine, contributing to the improvement of traditional modalities while facilitating the development of novel applications.
In many cases, synthetic functionalization strategies are effective in replicating distinct biological interactions.