University of Maryland Global Campus

BIOL 105: Principles of Biology I

A study guide to UMGC's 4-credit biology course for science majors, with a special emphasis on cellular and molecular biology.

Updated October 2026 · 5 min read

BIOL 105 Principles of Biology I is a 4-credit course at the University of Maryland Global Campus designed for students majoring in science.

UMGC describes it as an introduction to the basic principles of biology, with the goal of applying knowledge of biological principles, the scientific method and quantitative reasoning to communicate an understanding of biological topics and research effectively.

Topics include the scientific method and biological processes and functions, with a special emphasis on cellular and molecular biology. It fulfills the laboratory science requirement.

Because it is aimed at science majors, BIOL 105 goes deeper into cells and molecules than UMGC's general education biology courses. Students find it challenging because it expects precise use of terminology, comfort with numbers and the ability to explain research clearly in writing.

Course at a Glance

ItemDetails
UniversityUniversity of Maryland Global Campus (UMGC)
Course codeBIOL 105
Credits4
AudienceStudents majoring in science
RequirementFulfills the laboratory science requirement
Typical workLab reports, problem sets, research summaries, exams

What BIOL 105 Covers

TopicIn plain language
The scientific methodHow biologists design and test ideas
Biological processes and functionsHow living systems carry out their work
Cellular biologyCell structures, membranes, transport and energy
Molecular biologyDNA, RNA, proteins and how genetic information is used
Quantitative reasoningMeasurements, calculations and data interpretation
Communicating biologyExplaining topics and research clearly and accurately

Key Concepts Explained

Membrane Transport

Small nonpolar molecules diffuse through membranes; ions and larger polar molecules need protein channels or carriers; moving substances against a concentration gradient requires energy (active transport), as in the sodium-potassium pump.

Enzymes

Enzymes are proteins that speed reactions by lowering activation energy. Their activity depends on temperature, pH and substrate concentration, and inhibitors can reduce it.

Example: In an enzyme lab, reaction rate rises as substrate concentration increases, then levels off. Explanation: at low concentrations, more substrate means more collisions with active sites; at high concentrations, all active sites are occupied (the enzyme is saturated), so adding substrate no longer speeds the reaction. Stating both the pattern and its molecular cause is what strong answers do.

Communicating Research

UMGC's description emphasizes communicating an understanding of biological topics and research. When summarizing a study, state the question, method, key result and limitation in your own words.

Typical Assignments and How to Approach Them

Follow your syllabus and rubric. Courses with this focus typically include:

Assignment typeWhat it testsHow to approach it
Lab reportScientific method and analysisClear hypothesis, precise methods, graphed results and reasoned discussion
Research summaryCommunicating researchQuestion, method, result, limitation, in plain scientific language
Problem setsQuantitative reasoningShow working and units, then interpret the answer
ExamsCellular and molecular understandingExplain processes step by step, with diagrams where helpful

The Molecular Core

Because BIOL 105 emphasizes cellular and molecular biology, expect to work with DNA structure, replication, transcription and translation. DNA is a double helix of two antiparallel strands held together by complementary base pairs (A with T, G with C).

Replication is semi-conservative: each new molecule keeps one original strand. Genes are transcribed into mRNA and translated into proteins at ribosomes.

Questions often ask you to predict the effect of a change, such as a mutation that alters one base. Trace the effect step by step: the changed DNA codon, the changed mRNA codon, the amino acid (if any) that changes, and the possible effect on protein shape and function.

This step-by-step logic is what UMGC's emphasis on communicating biological understanding rewards.

Where Students Get Stuck

Study Tips for BIOL 105

How We Help with BIOL 105

Send the instructions, rubric, data and feedback. A biology tutor can explain cellular and molecular concepts, check your calculations, review your lab report or research summary or prepare a custom answer to learn from. Our lab report guide covers structure in depth.

GradeEssays is independent of the University of Maryland Global Campus. Our help is tutoring and reference material; you complete and submit your own work under UMGC's academic integrity policy, and we never take exams for students. Revisions within the scope of your original request are free.

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Frequently Asked Questions

Who is BIOL 105 for?

UMGC states that BIOL 105 is for students majoring in science.

How many credits is BIOL 105?

UMGC lists BIOL 105 at 4 credits.

Does BIOL 105 fulfill the lab science requirement?

Yes, according to UMGC's course description.

What does BIOL 105 emphasize?

Cellular and molecular biology, alongside the scientific method and quantitative reasoning.

How is BIOL 105 different from BIOL 103?

BIOL 103 is a general introduction not open to biotechnology or lab management majors; BIOL 105 is designed for science majors and emphasizes cellular and molecular biology.

Can you help me summarize a research article?

Yes. We explain the study and show how to summarize its question, method, results and limitations in your own words.