Western Governors University

C614: Biology: Content Knowledge

A study guide to WGU's C614, the comprehensive biology course that ties the secondary biology content sequence together for future teachers.

Updated October 2026 · 5 min read

C614 Biology: Content Knowledge is a comprehensive Western Governors University course that tests how well future biology teachers understand the subject as one connected whole.

WGU describes the course as examining your conceptual understanding of a broad range of biology topics, because high school biology teachers must help students make connections between isolated topics.

It begins with the macromolecules that make up cells, moves through cellular processes, links genetics and evolution, continues through classification and plant and animal development and systems, and finishes with ecology and human impact on the environment.

The challenge is the breadth. You need to recall facts across all of biology and, more importantly, explain how they connect.

Course at a Glance

ItemDetails
UniversityWestern Governors University (WGU)
Course codeC614
ProgramM.A. Science Education (Secondary Biological Science)
LevelGraduate, competency-based
Subject areaBiology content review
Typical workComprehensive review and assessment across biology

What C614 Covers

Sequence (from WGU's description)Key ideas
MacromoleculesCarbohydrates, lipids, proteins and nucleic acids
Cellular processesRespiration, photosynthesis, transport, division
Genetics and evolutionInheritance, DNA, natural selection
ClassificationDomains, kingdoms and evolutionary relationships
Plant and animal development and organ systemsStructure, function and homeostasis
Ecology and human impactEcosystems, cycles and environmental change

Making the Connections

Because the course stresses connections, practice linking topics in chains. Three useful chains:

From DNA to Evolution

DNA codes for proteins; mutations change proteins; some changes affect survival and reproduction; natural selection shifts allele frequencies over generations.

Example: Antibiotic resistance links molecular biology, genetics, evolution and human impact. A mutation alters a bacterial protein so the drug no longer binds; resistant bacteria survive treatment and multiply; overuse of antibiotics speeds the process. One example covers four parts of the course.

From Cells to Ecosystems

Photosynthesis in plant cells captures energy that flows through food webs, while cellular respiration in all organisms releases it. Linking the two equations to the carbon cycle connects cell biology to ecology.

Homeostasis Across Systems

Organ systems work together to keep internal conditions stable through feedback loops. Blood glucose regulation by insulin and glucagon is a classic negative feedback example.

Typical Assessment Work and How to Prepare

WGU assesses competency through performance assessments or objective assessments. Check your course page for the current format. Content review courses like this usually call for:

ActivityWhat it testsHow to prepare
Broad content questionsRecall across biologyReview each unit with spaced practice
Connection questionsLinking topicsPractice explaining chains of cause and effect
Data interpretationReading graphs and resultsDescribe trends and draw cautious conclusions
Teaching explanationsClarity for studentsExplain a concept simply with an analogy

A Review Plan for a Broad Course

Explaining Biology to High School Students

WGU's description of C614 is framed around teaching: helping high school students connect topics. Practicing explanations at that level is good preparation in its own right, because it exposes any gaps in your own understanding.

Useful techniques include:

Example: Asked where a tree's mass comes from, many people say the soil. In fact most of it comes from carbon dioxide in the air, fixed by photosynthesis. Explaining this links the carbon cycle, photosynthesis and macromolecules in one short answer.

Do Not Neglect Plant Biology

WGU's description moves from classification into plant and animal development. Plant biology is often the weakest area for students who studied human or animal biology. Review the essentials: plant tissues (xylem, phloem and meristems), transpiration and water transport, plant hormones such as auxin, and the alternation of generations in plant life cycles.

Comparing how plants and animals solve the same problems, such as gas exchange, transport and reproduction, is an efficient way to revise both and to practice the connection-making the course rewards.

Where Students Get Stuck

Study Tips for C614

How We Help with C614

Tell us the topics you find hardest, share any study guides or practice feedback, and a biology tutor prepares clear explanations, worked examples, concept maps and practice questions for your review. We can also review written explanations you draft.

GradeEssays is independent of Western Governors University. We offer tutoring and study material only: we never take exams or assessments for students and never log in to student portals. Revisions are free within the original scope.

Connect Every Biology Topic You Need to Teach

Share your study plan and weak areas. A biology tutor prepares clear explanations and practice to help you review.

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Frequently Asked Questions

What does C614 cover?

A broad review of biology for teachers: macromolecules, cellular processes, genetics and evolution, classification, plant and animal systems and homeostasis, and ecology and human impact.

Why does C614 emphasize connections?

WGU notes that high school biology teachers must help students connect isolated topics, so the course tests linked understanding.

How should I study for C614?

Review unit by unit in course order, use active recall and spaced practice, then build concept maps linking topics.

Which program includes C614?

It appears in WGU's M.A. Science Education (Secondary Biological Science). Check your program guide.

Can you take the C614 assessment for me?

No. We provide tutoring and study materials only.

Is GradeEssays affiliated with WGU?

No. We are an independent service with no connection to Western Governors University.