The enzyme Fumarase has the following kinetic constants: S

The enzyme Fumarase has the following kinetic constants: S + E ↔ ES → P + E where k1 and k-1 are the rate constants of the reversible reaction step (forward and reverse reaction, respectively) and k2is for the irreversible step. The values of k1,k ^_-1   ,and k2 are 10 ⁹   M ^-1   s ^-1   , 4.4 x 10 ⁴   s ^-1   , and 10 ³   s ^-1  .

(a) What is the value of the Michaelis constant for fumarase?

(b) At an enzyme concentration of 10 ^-6   M, what will be the initial rate of product formation at an initial substrate concentration of10 ^-3   M?